TB-500 is a synthetic peptide that corresponds to the sequence of thymosin beta-4, a naturally occurring actin-sequestering protein found in high concentrations in eukaryotic cells. It consists of 43 amino acids. Research focuses on its ability to uphold the cellular cytoskeleton through the regulation of actin polymerization, a process critical for cell motility and migration.
$84.00
| Quantity | 10 MG |
|---|
Independent Laboratory Verification
ANALYTICAL REFERENCE STANDARD: Synthesized Thymosin Beta-4 fragment sequence supplied for cytoskeletal modeling, cellular motility observation, and angiogenic assay development. Net purity threshold ≥99% verified via high-performance liquid chromatography (HPLC) and mass spectrometry (MS). Strictly for laboratory research use only.
TB-500 possesses the molecular formula C₂₁₂H₃₅₀N₅₆O₇₈S. It is chemically identical to the active region of Thymosin Beta-4 (Tβ4), a major actin-sequestering molecule. The peptide’s primary function in biological systems involves binding to G-actin (monomeric actin) and preventing its polymerization into F-actin filaments. This regulation is essential for maintaining cytoskeletal structure and facilitating cellular changes required for motility.
Scientific studies investigate the role of TB-500 in angiogenesis and tissue differentiation. In laboratory models, the peptide is observed to influence the migration of endothelial cells and keratinocytes. Researchers postulate that this activity is mediated not only by actin interaction but also through the upregulation of specific enzymes such as matrix metalloproteinases (MMPs), which degrade the extracellular matrix to allow for cell movement.
In murine models of cardiac and skeletal muscle injury, TB-500 is utilized to examine mechanisms of inflammation control and fibrosis reduction. Data suggests that the peptide may downregulate inflammatory cytokines and promote the survival of cardiomyocytes under stress conditions. It serves as a vital tool for understanding the molecular pathways of tissue regeneration and cellular defense.
LABORATORY COMPLIANCE DIRECTIVE: This product is strictly for laboratory and research purposes only. TB-500 is not intended for human use, diagnostic, or therapeutic procedures. It serves as an analytical reagent for scientific study and method validation.
